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What is the action of hydroxyurea? Mechanism of action Hydroxycarbamide decreases the production of deoxyribonucleotides via inhibition of the enzyme ribonucleotide reductase by scavenging tyrosyl free radicals as they are involved in the reduction of nucleoside diphosphates (NDPs).
What is hydroxyurea used for in sickle cell? Hydroxyurea, a myelosuppressive agent, is the only effective drug proven to reduce the frequency of painful episodes. It raises the level of HbF and the haemoglobin level. It usually decreases the rate of painful episodes by 50 %. It was first tested in sickle cell disease in 1984.
Is hydroxyurea the same as hydroxycarbamide? Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and polycythemia vera. In sickle-cell disease it increases hemoglobin and decreases the number of attacks. Hydroxycarbamide is in the antineoplastic family of medications.
When should I take hydroxyurea? Your doctor may occasionally change your dose. Use the medicine exactly as directed. Hydroxyurea is usually taken once per day at the same time of day, with or without food. Swallow the pill whole with a glass of water.
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